Development of better antidepressant using Nelumbinis Semen in an animal model of depression

Autor:	Moonkyu Kang, Kwang-Ho Pyun, Hyunsu Bae, Insop Shim
Rok vydání:	2006
Předmět:	medicine.medical_specialty Hippocampus General Medicine Nelumbinis Semen Serotonergic Endocrinology Animal model Mild stress Internal medicine medicine Antidepressant Serotonin Psychology Neuroscience Depression (differential diagnoses)
Zdroj:	International Congress Series. 1287:345-349
ISSN:	0531-5131
DOI:	10.1016/j.ics.2005.11.116
Popis:	Depression is associated with a dysfunctional 5-HT system. Recently, several lines of evidence have suggested that a very important evoking factor in depression may be a 5-HT deficit in the hippocampus. The present study assessed the antidepression effects of Nelumbinis Semen (NS) through increasing 5-HT concentrations in the hippocampus under chronic mild stress (CMS). NS significantly increased 5-HT in normal conditions and reversed a stress-induced decrease of 5-HT release in the hippocampus under CMS for 8 weeks. These results suggest that NS increases the serotonin levels normally decreased in depression, resulting in an enhancement of central serotonergic transmission and possible therapeutic action for depression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e36a256955b57b5e2f7c77a84f36f27d https://doi.org/10.1016/j.ics.2005.11.116 Zobrazit plný text záznamu Full Text from ScienceDirect