A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer
| Autor: | Uma G. Desai, Max C. Dietrich, Christopher L. Lee, C. Carl Jaffe, B. Nicolas Bloch, Suhong Yu, Ariel E. Hirsch, H.F. Xiang, Ankur Das |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
3d printed
medicine.diagnostic_test business.industry medicine.medical_treatment Magnetic resonance imaging Neurovascular bundle medicine.disease Imaging phantom 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Cyberknife 030220 oncology & carcinogenesis Medicine business Nuclear medicine Quality assurance |
| Zdroj: | Journal of Engineering and Science in Medical Diagnostics and Therapy. 1 |
| ISSN: | 2572-7966 2572-7958 |
| DOI: | 10.1115/1.4040817 |
| Popis: | This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, three-dimensional (3D)-printed phantom for external beam radiation therapy (EBRT) of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion (DIL), seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance (MR) images. The iterative process for designing the phantom based on user interaction and evaluation is described. Using the CyberKnife System at Boston Medical Center, a treatment plan was successfully created and delivered. Dosage delivery results were validated through gamma index calculations based on radiochromic film measurements which yielded a 99.8% passing rate. This phantom is a demonstration of a methodology for incorporating high-contrast MR imaging into computed-tomography-based radiotherapy treatment planning; moreover, it can be used to perform quality assurance (QA). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|