ANALGESIC AND ANTI-DIABETIC POTENTIAL OF ROYSTONEA REGIA
| Autor: | Muhammad Usama Munir, null Muhammad Asad Saeed, Zeeshan Masood, Nazia Aslam, Umer Farooq, Mohammad Farooq |
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| Rok vydání: | 2022 |
| Zdroj: | International Journal of Pharmacy & Integrated Health Sciences. 3:3-14 |
| ISSN: | 2789-2840 2958-1656 |
| Popis: | Background: Plants are the rich source of nutrients and contain biological and pharmacological potential. Roystonea regia, a plant of Aceraceae family has been traditionally used in different countries especially in Asia. Objectives: The aim of the study was to evaluate its analgesic and anti-diabetic potential by hot plate method and Alloxan induced method in Swiss albino female rats weighing 150 to 200 gm respectively. Methodology: Shoots of Roystonea regia plant was extracted using n-hexane, chloroform and ethanol in Soxhlet apparatus. Oral acute toxicity test showed the different mortality rates of all extracts. Results: The crude n-hexane and ethanol extract showed increase in the latency time till 120 min and were found to have significant (p˂0.001) analgesic potential at 100 and 200 mg/kg dose. However, different anti-diabetic potential was shown by all three extracts. Chloroform extract showed maximum reduction in blood glucose level (BGL) and found significant (p˂0.001) as compared to negative control till 21st day at the dose of 250 and 500 mg/kg of body weight. Conclusion: Further study is required to understand the complete mechanism involved in both activities. In future, purified fractions and column chromatography can be conducted for their complete characterization and their toxic effects to establish a proper therapeutic dose for further trials. |
| Databáze: | OpenAIRE |
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