Investigation of in vitro efficiency of magnetic nanoparticle-conjugated 125I-uracil glucuronides in adenocarcinoma cells
| Autor: | E. Ilker Medine, Perihan Ünak, Feriha Ozkaya, Serhan Sakarya |
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| Rok vydání: | 2011 |
| Předmět: |
Nanoparticle
Bioengineering Uracil General Chemistry Conjugated system equipment and supplies Condensed Matter Physics Atomic and Molecular Physics and Optics chemistry.chemical_compound chemistry Modeling and Simulation Yield (chemistry) Drug delivery Magnetic nanoparticles Nanomedicine Organic chemistry General Materials Science Glucuronide human activities Nuclear chemistry |
| Zdroj: | Journal of Nanoparticle Research. 13:4703-4715 |
| ISSN: | 1572-896X 1388-0764 |
| Popis: | Modification of the magnetic properties of a drug can be used to direct the drug to the desired site, enhancing its therapeutic effectiveness and reducing side effects. In this study, surface-modified magnetic nanoparticles were immobilized with uracil glucuronide derivatives and then labeled with I-125. The morphology, structure, and composition of the magnetic particles were examined by TEM, SEM, VSM, and XRD. The particles sizes were about 50 nm. The labeling yield was 93.8% for uracil-O-glucuronide-immobilized magnetic particles and 95.0% for uracil-N-glucuronide-immobilized magnetic particles. The cell incorporation rates of N- and O-glucuronides were higher than those of uracil. The incorporation rates of uracil-, O-glucuronide-, and N-glucuronide-conjugated magnetic particles were all high. The cell incorporation rates of ligand-conjugated magnetic particles increased under a magnetic field. |
| Databáze: | OpenAIRE |
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