mda-7/IL-24, A Novel Cancer Selective Apoptosis Inducing Cytokine Gene: From the Laboratory into the Clinic
| Autor: | Rahul V. Gopalkrishnan, David T. Curiel, Myrna R. Rosenfeld, Rajagopal Ramesh, Paul Dent, Paul B. Fisher, Elizabeth A. Grimm, Sunil Chada |
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| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Cancer Biology & Therapy. 2:22-36 |
| ISSN: | 1555-8576 1538-4047 |
| Popis: | An obstacle to effective gene-based cancer therapies is the limited number of cancer-specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction subtraction hybridization (DISH) approach with human melanoma cells, melanoma differentiation associated (mda) genes were isolated that display elevated expression as a function of irreversible growth arrest, cancer reversion and terminal differentiation. This screening paradigm resulted in the cloning of mda-7 in the context of terminal differentiation of human melanoma cells. Based on its structure, chromosomal location, sequence homology and cytokine-like properties, mda-7 has now been renamed IL-24 and classified as a member of the expanding IL-10 cytokine gene family. Expression of mda-7/IL-24 inversely correlates with melanoma progression and administration of mda-7/IL-24 by means of a replication incompetent adenovirus, Ad.mda-7, results in growth suppression and apoptosis in melanoma cells as well as in a broad-spectrum of ... |
| Databáze: | OpenAIRE |
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