Immunotherapy of Malignant Tumors Using Antisense Anti-IGF-I Approach: Case of Glioblastoma

Autor:	Annabelle Trojan, Lina Manuela Jay, Heliodor Kasprzak, Jerzy Trojan, Donald D. Anthony
Rok vydání:	2014
Předmět:	Chemotherapy business.industry medicine.medical_treatment Cell Cancer Immunotherapy Transfection medicine.disease Radiation therapy medicine.anatomical_structure Immune system Immunology medicine Cancer research business CD8
Zdroj:	Journal of Cancer Therapy. :685-705
ISSN:	2151-1942 2151-1934
DOI:	10.4236/jct.2014.57078
Popis:	The review article describes the criteria established for methodology of antisense anti IGF-I therapy of malignant tumors, particularly of glioblastoma. The cancer patients, after classical therapy of surgery, radiotherapy and chemotherapy, have undergone the injection of genetically modified autologous malignant cells—transfected by IGF-I antisense/triple helix expression vectors. For all cancer patients supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients, the following common immune criteria for “anti IGF-I” strategy were admitted: 1) characteristics of cell “vaccines”—absence of IGF-I and expression of MHC-I in cloned transfected cells; 2) the peripheral blood lymphocytes, PBL cells, removed after every of two successive vaccinations, demonstrate an increasing level of CD8+ and CD8+28+ molecules (with a switch from CD8+11b+ to CD8+11b-).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3463d26d58861654a541cd08c43a865 https://doi.org/10.4236/jct.2014.57078 Zobrazit plný text záznamu