Rheology Effects on Mucus Plug Rupture

Autor: James B. Grotberg, Shiyao Bian, Marcel Filoche, John C. Grotberg, Shuichi Takayama, Yingying Hu
Rok vydání: 2013
Předmět:
Zdroj: Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments.
DOI: 10.1115/sbc2013-14507
Popis: Human respiratory mucus has non-Newtonian rheological properties of viscoelasticity, shear-thinning and yield stress. They play significant roles in mucus clearance by ciliary motion as well as cough [5,7,9]. Mucus is hypersecreted in such lung diseases as cystic fibrosis and asthma. Mucus hypersecretion damages mucus clearance mechanism [6], and more likely causes plugs to block partial or total airways [4].Copyright © 2013 by ASME
Databáze: OpenAIRE