The outcome of children requiring admission to an intensive care unit following bone marrow transplantation
| Autor: | Colin G. Steward, Richard J. Lush, Derwood Pamphilon, John Henderson, Anthony Oakhill, David I. Marks, Corinne Hayes, Jacqueline M. Cornish, Patricia Weir, Peter Murphy, Ian Jenkins, Annabel M. Foot, Andrew R. Wolf |
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| Rok vydání: | 1998 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty business.industry Anemia medicine.medical_treatment Retrospective cohort study Hematology Lung injury medicine.disease Intensive care unit Surgery law.invention Respiratory failure law Acute lymphocytic leukemia Emergency medicine medicine Aplastic anemia business |
| Zdroj: | British Journal of Haematology. 102:666-670 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1998.00817.x |
| Popis: | We report the results of a retrospective study of the role of intensive care unit (ICU) admission in the management of 367 children who underwent bone marrow transplantation (BMT) at a tertiary referral institution. 39 patients (11%) required 44 ICU admissions for a median of 6 d. 70% received marrow from unrelated donors, half of which were mismatched; 80% had leukaemia and two-thirds were considered high-risk transplants. Respiratory failure was the major reason for admission to ICU. 75% of admissions required mechanical ventilation (for a median of 5 d) and 20 patients had lung injury as defined by the criteria of the Seattle group. None of 11 patients with proven viral pneumonitis survived (P = 0.06) and only one of 20 patients with lung injury survived (P 6 months. ICU admission can be beneficial to selected children post-BMT but it may be less useful in proven viral pneumonitis. Where mechanical ventilation is required, the duration of this support should be limited unless there is rapid improvement. |
| Databáze: | OpenAIRE |
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