From domino to multicomponent: synthesis of dihydroisobenzofurans

Autor: Elisabetta Rossi, Monica Dell'Acqua, Giorgio Abbiati, Diego Facoetti
Rok vydání: 2011
Předmět:
Zdroj: Tetrahedron. 67:1552-1556
ISSN: 0040-4020
DOI: 10.1016/j.tet.2010.12.056
Popis: A variety of substituted dihydroisobenzofurans can be easily synthesized in high yields by a one-pot three-component approach starting from o-bromoarylaldehydes, methanol, and terminal alkynes. The reaction occurs through an unprecedented cooperative palladium/base promoted coupling/addition/cyclization sequence.
Databáze: OpenAIRE