Acute intraperitoneal toxicity of ochratoxins A and B in rainbow trout (Salmo gairdneri)
| Autor: | R.C. Doster, J.H. Wales, R.O. Sinnhuber |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Ochratoxin A
medicine.medical_specialty Pathology Necrosis biology food and beverages Toxicology biology.organism_classification Median lethal dose Ochratoxins Trout chemistry.chemical_compound Endocrinology chemistry Internal medicine Toxicity medicine medicine.symptom Aspergillus ochraceus Ochratoxin |
| Zdroj: | Food and Cosmetics Toxicology. 10:85-92 |
| ISSN: | 0015-6264 |
| DOI: | 10.1016/s0015-6264(72)80049-x |
| Popis: | The acute intraperitoneal toxicities of two metabolites of Aspergillus ochraceus , ochratoxins A and B, and their dihydroisocoumarin derivatives, ochratoxins a and b , were studied in 6-month-old Mt. Shasta strain rainbow trout ( Salmo gairdneri ). Ochratoxin A was the only compound found to be lethal to trout at the levels administered, its acute intraperitoneal LD 50 being 4·67 mg/kg. Pathological changes in the liver and kidneys were produced by ochratoxins A and B but not by ochratoxin a or b . Ochratoxin A produced degenerative changes in the hepatic parenchymal cells, including nuclear swelling and cytoplasmic and nuclear lipid vacuolation, necrosis in the proximal tubules, haematopoietic tissue and glomeruli of the kidneys and pycnotic nuclei, cast formation and lipid vacuolation in the renal tubules. Ochratoxin B administered at levels up to 66·7 mg/kg caused no deaths but the highest dose induced pathological changes in the liver and kidneys similar to those produced by relatively low levels of ochratoxin A. Ochratoxins a and b administered at levels up to 28·0 and 26·7 mg/kg, respectively, failed to cause any deaths or induce any microscopic lesions that were not seen in control trout dosed with 0·1 n -sodium bicarbonate. It is suggested that ochratoxins A and B are metabolized to their non-toxic water-soluble dihydroisocoumarin moieties, which are readily excreted. |
| Databáze: | OpenAIRE |
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