Regioselective acylation of 2-methoxy naphthalene catalyzed by supported 12-phosphotungstic acid

Autor:	Vidavalur Siddaiah, Avala Vedamayee Devi, Kishor Rajdeo, Nitin W. Fadnavis, Thenkrishnan Kumaraguru
Rok vydání:	2014
Předmět:	Zirconium Silica gel Process Chemistry and Technology chemistry.chemical_element Tetrachloroethane Catalysis Acylation chemistry.chemical_compound Acetic anhydride chemistry Organic chemistry Phosphotungstic acid Selectivity
Zdroj:	Applied Catalysis A: General. 486:55-61
ISSN:	0926-860X
DOI:	10.1016/j.apcata.2014.08.026
Popis:	12-Phosphotungstic acid supported on silica gel, zirconium sulfate, and a combination of silica gel and zirconium sulfate (50% w/w) were employed as solid acid catalysts for regioselective acylation of 2-methoxynaphtalene with acetic anhydride. 1-(6-Methoxynaphthalen-2-yl)ethanone (2,6-AMN), a commercially important intermediate for production of Naproxen, was obtained with excellent selectivity (>98%) at 67–68% conversion using 12-phosphotungstic acid supported on silica gel 20% (w/w) in refluxing tetrachloroethane. The unreacted starting material can be easily separated from the product by a simple crystallization from nonane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e32cee99f37c638a93184919b4e64dee https://doi.org/10.1016/j.apcata.2014.08.026 Zobrazit plný text záznamu Full Text from ScienceDirect