Some aspects of the search for a human mammary tumor virus

Autor: Etienne Y. Lasfargues, Jesse Charney, Dan H. Moore, Nurul H. Sarkar, Bernhard Kramarsky
Rok vydání: 1971
Předmět:
Zdroj: Cancer. 28:1415-1424
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(197112)28:6<1415::aid-cncr2820280614>3.0.co;2-z
Popis: Some aspects of the search for a human breast cancer virus are discussed. Milk from 3 groups of women were studied: 1) Parsis India women 2) American women with a family history of breast cancer and 3) controls which were American woman with no history of breast cancer in their families. Viruslike (Type B) particles structurally similar to or identical with those responsible for transmitting mammary tumors in mice were found in 39% of 46 Parsis milks 31% of 101 milks of high-risk American women and 12% of 181 controls. However the incidence of breast cancer in the Parsis of Bombay was not much different from that in the U.S. (50-55/year/100000 population). This study was subject to error because screening for B particles by electron microscopy is extremely difficult and dependent on chance and the recognition of a B particle is not always absolute. It would seem that possibly inbreeding has resulted in an unusually high incidence of virus carriers but other factors have conveyed a high resistance to other cancers in Parsis. Studies on the effect of being breast-fed and the risk of developing breast cancer may be helpful in finding a prophylaxis for virus-caused breast cancer.
Databáze: OpenAIRE
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