Putative Role of Ligands of DNIC in the Physiological Action of the Complex

Autor:	A. M. Dolgorukova, V. Yu. Titov, I. I. Kochish, A. N. Osipov
Rok vydání:	2021
Předmět:	animal structures Diffuse noxious inhibitory control Avian embryo Embryo General Medicine Metabolism General Biochemistry Genetics and Molecular Biology No donors Cell biology chemistry.chemical_compound chemistry embryonic structures Nitrite Function (biology)
Zdroj:	Bulletin of Experimental Biology and Medicine. 171:606-610
ISSN:	1573-8221 0007-4888
Popis:	In a relatively isolated system of avian embryo, the metabolism of NO, a component of the dinitrosyl iron complexes (DNIC), the main NO donor in most tissues, depends on the ligands that make up the complex. This fact corroborates the earlier hypothesis that these ligands perform a regulatory function in NO metabolism. It is also shown that nitrite injected into the embryo is not oxidized to nitrate like NO in DNIC, but is accumulated outside the amniotic sac. Normally, nitrite is present in an embryo in trace amounts. These facts suggest that NO in the embryo is transferred from the donor molecule to a target in the embryo tissues further transformed with minimum oxidation to nitrite.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3250b4a99f1555556d6fa7d81c105b1 https://doi.org/10.1007/s10517-021-05278-1 Zobrazit plný text záznamu Full text from SpringerLink