793 Obstructive Sleep Apnea and Hypoventilation in Patients with Muscular Dystrophies: Analysis of 42 Polysomnogram Studies
| Autor: | Pallav Halani, Travis Ewing, Bradley V. Vaughn, Zheng Fan, Mihye Ahn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Muscular dystrophy limb-girdle
medicine.medical_specialty medicine.diagnostic_test business.industry Polysomnogram Polysomnography medicine.disease End tidal carbon dioxide concentration respiratory tract diseases Hypoventilation Obstructive sleep apnea Physiology (medical) Internal medicine medicine Cardiology In patient Neurology (clinical) medicine.symptom business Hypercapnia |
| Zdroj: | Sleep. 44:A309-A309 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/zsab072.790 |
| Popis: | Introduction Patients with muscular dystrophies (dystrophinopathy, congenital muscular dystrophy and limb-girdle muscular dystrophy) are at greater risk of obstructive sleep apnea (OSA). However, few studies have examined if they are also at risk for hypoventilation and its relationship with OSA. We hypothesize that these two conditions occur independently of each other as an impaired ventilator drive and diaphragm weakness. Methods Retrospective review of diagnostic polysomnograms (PSG) in a tertiary care facility over 15 years was conducted. The polysomnography included either end tidal CO2 or transcutaneous CO2 measurements. Descriptive data analysis was performed on results described. We computed Pearson correlation coefficients to examine the relationships between PSG indices and other parameters. Pearson’s Chi-squared test with Yates’ continuity correction is used to test if hypoventilation is independent from OSA. Results 42 PSG studies in patients with muscular dystrophies were included after excluding 2 studies due to insufficient sleep duration. The average age at the time of study was 14.2 yrs with 41 being male and average BMI of 24.1. 64% of the group met the definition for OSA with average AHI 8.0. 36% of the group met the criteria for hypoventilation, and 33% patients with hypoventilation did not have OSA. Chi squared analysis (p=1.0) shows that hypoventilation is independent of OSA. Conclusion Sleep disordered breathing is common in patients with muscular dystrophy. This study supports that OSA and CO2 retention may be independent processes. Support (if any) |
| Databáze: | OpenAIRE |
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