Single-Molecule Protein Fingerprinting with Nanopores

Autor: Aleksei Aksimentiev, Shalini John, Misha Soskine, Laura Restrepo-Pérez, Giovanni Maglia, Cees Dekker, Chirlmin Joo
Rok vydání: 2017
Předmět:
Zdroj: Biophysical Journal. 112:330a
ISSN: 0006-3495
Popis: Proteins are the most abundant biomolecules in the human body. Proteomics is instrumental to understand and detect diseases. Despite the importance of protein analysis, only a handful of techniques are available to determine protein sequences and these face limitations, for example in the sizeable sample volume needed. During the last few decades, nanopore technology has emerged as one of the most promising techniques to sequence DNA. Sequencing proteins at the single-molecule level is a clear next step.
Databáze: OpenAIRE