Resveratrol Oligosaccharides (Gluco-Oligosaccharides) Effectively Inhibit SARS-CoV-2 Infection: Glycoside (Polysaccharide) Approach for Treatment of COVID-19
| Autor: | Hatsuyuki Hamada, Takafumi Iwaki, Atsuhito Kuboki, Kei Shimoda, Yuya Kiriake, Kohji Ishihara, Hiroki Hamada |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) 010405 organic chemistry Chemistry viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fungi Glycoside Plant Science General Medicine Resveratrol Polysaccharide 01 natural sciences respiratory tract diseases 0104 chemical sciences Microbiology body regions 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Polyphenol Drug Discovery skin and connective tissue diseases |
| Zdroj: | Natural Product Communications. 16:1934578X2110129 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x211012903 |
| Popis: | To examine the anti-SARS-CoV-2 effects of resveratrol oligosaccharides, human MRC5 lung cells, which had been infected with SARS-CoV-2, were incubated with different concentrations of resveratrol oligosaccharides. These suppressed the cell death induced by SARS-CoV-2 infection, more efficiently, at 0.1% concentration, than resveratrol itself. Resveratrol oligosaccharides effectively inhibited SARS-CoV-2 infection in the 5% to 10% concentration range, which indicates that these compounds could be useful anti-SARS-CoV-2 agents. |
| Databáze: | OpenAIRE |
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