New heterocyclic derivatives of benzimidazole with germicidal activity

Autor:	Bastianini L, E Lepri, G. A. Bistocchi, Giovanni De Meo, Pedini M
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Benzimidazole Aromatase inhibitor biology medicine.drug_class Nitro compound Pharmaceutical Science In vitro chemistry.chemical_compound Enzyme chemistry Biochemistry Enzyme inhibitor Drug Discovery biology.protein medicine Aromatase Aminoglutethimide medicine.drug
Zdroj:	Il Farmaco. 54:327-330
ISSN:	0014-827X
DOI:	10.1016/s0014-827x(99)00018-x
Popis:	Several benzimidazole derivatives have been tested in vitro for their ability to inhibit human placental aromatase activity. The results show that five out of the six compounds tested are more active in the inhibition of aromatase activity than aminoglutethimide (AG), which we chose as the reference compound and which, as an aromatase inhibitor, is currently being used in the treatment of metastatic breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e320a15a6cf3153a2572c45fd91d051e https://doi.org/10.1016/s0014-827x(99)00018-x Zobrazit plný text záznamu Full Text from ScienceDirect