Abstract 806: Anti-tumor effects of low temperature whole body hyperthermia on human bladder cancer cells in vivo
| Autor: | Kazuhiro Yoshimura, Ayaka Izumi, Yi Wang, Nobutaka Shimizu, Makiko Doi, Kazuhiro Yoshikawa, Masahiro Nozawa, Hirotugu Uemura, Yuji Hatanaka, Erina Okazaki, Marco A. De Velasco, Yutaka Yamamoto |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Cancer Research. 71:806-806 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2011-806 |
| Popis: | As a whole, the concept of thermotherapy is still under study. However, there is an abundant amount basic and pre-clinical published reports that have shown the antitumor effects of hyperthermia in various cancer models. Local, regional and whole body hyperthermia (WBH) has been studied and the effectiveness of the treatment depends largely on the temperature achieved and the duration of treatment. High temperatures, low duration (heat shock) will have a direct killing effect on exposed cells. The limitation to this approach is the restriction of tumor location. Low temperature, high duration WBH is generally considered to be the least toxic but requires long exposures that are generally uncomfortable or inconvenient to the patients. In this study we investigate the therapeutic efficacy of a synthetic far-infrared emitting biomaterial (BR), capable of inducing mild whole body hyperthermia, alone or in combination with chemotherapy against bladder cancer cell lines in vivo. Immunocompetent and immunodeficient mice were inoculated with a human superficial bladder cancer cell (KU7/GFP) or mouse bladder cancer cell (NBT2), respectively, and treated with BR alone or in combination with doxorubicin (Dox). Mice exposed to BR increased their core body temperature by 1oC (P Our data suggests that WBH may induce mild antitumor effects; although, the precise mechanism is still unclear, it appears that it may be due to an immuno-stimulatory effect. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 806. doi:10.1158/1538-7445.AM2011-806 |
| Databáze: | OpenAIRE |
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