Effect of ethosuximide on rest tremor in the MPTP monkey model
| Autor: | Paul J. Bédard, René Boucher, Baltazar Gomez-Mancilla, Jean-François Latulippe |
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| Rok vydání: | 1992 |
| Předmět: |
Agonist
medicine.medical_specialty Voltage-dependent calcium channel medicine.drug_class business.industry MPTP Thalamus nervous system diseases chemistry.chemical_compound Endocrinology Ethosuximide Neurology chemistry Internal medicine Dopamine receptor D2 medicine Verapamil Neurology (clinical) Diltiazem business medicine.drug |
| Zdroj: | Movement Disorders. 7:137-141 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.870070207 |
| Popis: | Based on the hypothesis that low-threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the anti-tremor effect of the dopamine D2 agonist LY-171555. |
| Databáze: | OpenAIRE |
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