Effects of ‘NEOGEN V.BIOME LIPOSOME™’ on the Increased Expression of COL1A1 and HAS2 mRNA in Human Dermal Fibroblasts
| Autor: | Ye Eun Joo, Seung Bin Kwon, Yu Jeong Kwon, Young Wook Choi, Mi Jung Kim, Meiling Sun, Kyu Joong Ahn, In-Sook An |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Asian Journal of Beauty and Cosmetology. 20:451-459 |
| ISSN: | 2466-2054 2466-2046 |
| DOI: | 10.20402/ajbc.2022.0070 |
| Popis: | Purpose: This study investigated functional cosmetic agent for anti-wrinkle effects of 'NEOGEN V.BIOME LIPOSOME™', which is a liposome in the form of a proprietary technology including a vitamin C active ingredient, on human dermal fibroblasts (HDFs).Methods: The cytotoxicity of 'NEOGEN V.BIOME LIPOSOME™' was measured by performing a water-soluble tetrazolium salt (WST-1) assay. The relative mRNA expression of collagen (COL1A1 ) and hyaluronan synthase (HAS2) was measured by quantitative real-time PCR (qRT-PCR) assay.Results: HDF cell viability of 'NEOGEN V.BIOME LIPOSOME™' was no cytotoxic effect at concentrations below 0.25%. The expression of COL1A1 and HAS2 mRNA was increased in a concentration-dependent manner compared with the negative control group.Conclusion: “NEOGEN V.BIOME LIPOSOME™“ helps to increase collagen and hyaluronan synthase production by promoting COL1A1 and HAS2 mRNA expression in HDFs; therefore, it is expected to function as an anti-wrinkle cosmetic material. |
| Databáze: | OpenAIRE |
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