Syncope Following Sofosbuvir Therapy for Chronic Hepatitis C: A Report of Two Cases
| Autor: | Sanhoury Mi, Lashen Sa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Hepatitis
medicine.medical_specialty Pediatrics Sofosbuvir biology medicine.diagnostic_test medicine.drug_class business.industry medicine.medical_treatment Syncope (genus) Liver transplantation Amiodarone medicine.disease biology.organism_classification Surgery Chronic hepatitis medicine Antiviral drug Liver function tests business medicine.drug |
| Zdroj: | Journal of Liver Research, Disorders & Therapy. 2 |
| ISSN: | 2471-1381 |
| DOI: | 10.15406/jlrdt.2016.02.00032 |
| Popis: | The recently approved direct acting antiviral drug, Sofosbuvir, represents a revolution in treatment of chronic hepatitis C infection. Little is known about its long term side effects. Recent reports had drawn the attention to the possible cardio-toxic effect of sofosbuvir when combined with amiodarone. In our cases we reported occurrence of syncopal attacks in two cases few days after administration of sofosbuvir. Syncope was triggered by suddenly standing up from setting position in one patient and by micturition in the other. We suggest the occurrence of autonomic disturbance following sofosbuvir intake, an observation which need further post marketing evaluation in a large number of cases to clarify the cardio-autonomic effects of sofosbuvir. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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