Investigation of the toxins of the venom of the spiderLinothele sp

Autor:	L. Ya. Yukel'son, B. U. Atakuziev
Rok vydání:	1996
Předmět:	Chromatography Chemistry Toxicity Size-exclusion chromatography Venom Plant Science General Chemistry Mass spectrometry High-performance liquid chromatography General Biochemistry Genetics and Molecular Biology
Zdroj:	Chemistry of Natural Compounds. 32:201-204
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf01373859
Popis:	Two low-molecular-mass toxins — Lsl and Ls2 — have ben isolated from the venom of a spiderLinothele sp. (fam. Dipluridae) with the aid of gel filtration and reversed phase high-performance liquid chromatography (HPLC). It hs been shown that they are highly toxic on cerebroventricular injection into white mice: the LD-50 values of toxins Lsl and Ls2 are 24 and 19 μg/kg, respectively, which are 25 and 31 time greater than the toxicity, of the whole venon, the LD-50 of which is 0.6 mg/kg. According to mass spectrometry the molecular masses of toxins Ls1 and Ls2 are 337 and 505 Da, while their yields were, respectively, 0.21 and 0.43 % of the weight of the whole venom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2f0557723e21c14bc96da1ed608d762 https://doi.org/10.1007/bf01373859 Zobrazit plný text záznamu Full text from SpringerLink