Effects of behavioral stimuli on plasma interleukin-1 activity in humans at rest

Autor:	Steven H. Heffeneider, David H. Regan, Sharon McCoy, William H. Keppel, Fred L. Ramsey
Rok vydání:	1993
Předmět:	Baseline values medicine.medical_specialty Interleukin Stimulation Stimulus (physiology) Serum samples Surgery Clinical Psychology Disease susceptibility Endocrinology Immune system Arts and Humanities (miscellaneous) Internal medicine Concomitant medicine Psychology
Zdroj:	Journal of Clinical Psychology. 49:777-789
ISSN:	1097-4679 0021-9762
DOI:	10.1002/1097-4679(199311)49:6<777::aid-jclp2270490605>3.0.co;2-2
Popis:	Interleukin-1 (IL-1) bioassays were done on 208 serum samples drawn from 7 volunteers, over several hours at 5-minute intervals, before, during, and after a relaxation-related behavioral stimulus. Individuals showed up to a 267% increase (t[29] = 7.750, p = 1 x 10(-7).) in IL-1, and for the group, a mean 48.1% elevation (t[5] = 4.128, p = .003) occurred, during the stimulus interval relative to baseline. When baselines were repeated, IL-1 activity rapidly returned toward baseline values. Suggestions to picture one's immune cells fighting illness appeared to have no uniform effect for all subjects. Such rapid changes in plasma IL-1, concomitant with stimuli, indicate a new way to alter immune function and further understand disease susceptibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2f000c254b323ca00f0a6ac41450ae2 https://doi.org/10.1002/1097-4679(199311)49:6<777::aid-jclp2270490605>3.0.co Zobrazit plný text záznamu