Stem cells of the liver
| Autor: | C. E. Sarraf, V. Emons, Malcolm R. Alison, Matthew Golding, Thapasimuthu V. Anilkumar |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Ductal cells Regeneration (biology) Amniotic stem cells General Medicine Biology digestive system Liver regeneration Pathology and Forensic Medicine Cell biology Endothelial stem cell Endocrinology Internal medicine medicine Anatomy Progenitor cell Stem cell Molecular Biology Adult stem cell |
| Zdroj: | Medical Electron Microscopy. 31:53-60 |
| ISSN: | 1860-1499 0918-4287 |
| DOI: | 10.1007/bf01557781 |
| Popis: | Liver regeneration can be accomplished either by the entry of normally proliferatively quiescent, differentiated hepatocytes into the cell cycle or, if hepatocyte regeneration is impaired, by bile ductular cells that migrate centrifugally from the portal tracts before differentiating into hepatocytes. These ductal cells are called oval cells, and their emergence when hepatocyte regeneration is defective has led to the conclusion that they are the progeny of facultative stem cells. Oval cells are of great biological interest because they may be the progenitor cells of both hepatocellular carcinomas and cholangiocarcinomas; furthermore, they could be useful vehicles for ex vivo gene therapy for the correction of inborn errors of metabolism. |
| Databáze: | OpenAIRE |
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