Therapie des Ulcus ventriculi mit Sucralfat und Ranitidin: Eine multizentrische Doppelblindstudie

Autor:	A. L. Blum, J. Ch. Bode, W. Domschke, G. Feurle, K. Hackenberg, B. Hammer, W. Hüttemann, G. Kachel, H. Kaess, B. C. Manegold, P. Peter, T. Pfleiderer, H. G. Rohner, U. Rasenack, R. Sanwald, G. A. Stalder, J.-J. Vallotton
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Stomach Endoscopic biopsy medicine.medical_treatment General Medicine Gastroenterology Ranitidine Double blind study Sucralfate Benign gastric ulcer medicine.anatomical_structure Antacid Internal medicine medicine business medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 111:1910-1915
ISSN:	1439-4413 0012-0472
Popis:	134 outpatients with acute benign gastric ulcer confirmed by endoscopic biopsy received either 1 g sucralfate suspension four times daily or one 150 mg ranitidine tablet twice daily for six to 12 weeks in a multicentre therapy study (double-blind study according to the double-dummy technique). After six to 12 weeks, respectively, 56% and 82% of the ulcers had healed in the sucralfate group. The rates of healing in the ranitidine group were 72% and 88%, respectively. The differences in the rates of healing between sucralfate and ranitidine were not statistically significant. Ranitidine was superior to the sucralfate suspension in corpus ulcer. In the distally located ulcers, the two kinds of treatment were equivalent. There were no appreciable differences between the medications with regard to antacid consumption and compliance. Gastric pain was influenced better by ranitidine than by sucralfate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2ecd605fa45fbcf57a321bd800930c7 https://doi.org/10.1055/s-2008-1068734 Zobrazit plný text záznamu