Memantine Promotes Bactericidal Effect of Neutrophils Against Infection with Pseudomonas aeruginosa and Its Drug-Resistant Strain, by Improving Reactive Oxygen Species Generation
| Autor: | Tiesong Zhang, Li-Ting Zeng, Yi Xiao, Sheng-He Huang, Shaojie Yang, Ying-Hua Li, Xiao-Yan Deng, Chen-Fei Liu, Liang Peng |
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| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Pharmacology chemistry.chemical_classification Reactive oxygen species Pseudomonas aeruginosa Chemistry Immunology Inflammation Drug resistance medicine.disease_cause Acquired immune system Microbiology Antibiotic resistance In vivo Amikacin embryonic structures medicine medicine.symptom medicine.drug |
| Zdroj: | Microbial Drug Resistance. 28:7-17 |
| ISSN: | 1931-8448 1076-6294 |
| DOI: | 10.1089/mdr.2020.0511 |
| Popis: | Pseudomonas aeruginosa is an opportunistic pathogen, which usually presents multiple antibiotic resistance. Host-directed therapy involves modulating the host defense system and the interplay between innate and adaptive immunity is a new strategy for designing anti-infection drugs. Memantine (MEM), a drug used to treat Alzheimer's disease, has a good inhibitory effect on neonatal mice with Escherichia coli-associated bacteremia and meningitis; however, the inhibitory effect and mechanisms of MEM against P. aeruginosa infection remain unclear. Here, we investigated whether MEM could inhibit P. aeruginosa infection and explored the potential mechanisms. MEM significantly promoted the bactericidal effect of neutrophils against P. aeruginosa and its drug-resistant strain. The combination index of MEM and amikacin (AMK) was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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