Invasive Mold Infections After Chimeric Antigen Receptor–Modified T-Cell Therapy: A Case Series, Review of the Literature, and Implications for Prophylaxis
| Autor: | Rafic Farah, Tatiana Bogdanovich, M. Hong Nguyen, Ghady Haidar, Palash Samanta, Kathleen A. Dorritie |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Mucorales biology business.industry Chimera organism T cell Neutropenia medicine.disease biology.organism_classification Chimeric antigen receptor 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases medicine.anatomical_structure Antigen Steroid use 030220 oncology & carcinogenesis Immunology Medicine In patient business |
| Zdroj: | Clinical Infectious Diseases. 71:672-676 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Data on invasive mold infections (IMIs) after chimeric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited. We describe 2 patients with post–CAR-T-cell IMI (Fusarium, Mucorales) and review the published literature. We propose strategies to prevent IMIs in patients, based on the IMI rate and presence of neutropenia or steroid use. |
| Databáze: | OpenAIRE |
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