Bolus intravenous 0.9% saline leads to interstitial permeability pulmonary edema in healthy volunteers
Autor: | Elena Cavallaro, Shailesh Bihari, Hanmo Li, Ubbo F Wiersema, Dani-Louise Dixon, David Schembri, Andrew D. Bersten |
---|---|
Rok vydání: | 2021 |
Předmět: |
medicine.diagnostic_test
Physiology business.industry medicine.medical_treatment Public Health Environmental and Occupational Health General Medicine Lung injury Doppler echocardiography Pulmonary edema medicine.disease Pulmonary function testing Bolus (medicine) Bronchoalveolar lavage Physiology (medical) Anesthesia medicine Orthopedics and Sports Medicine business Saline Blood sampling |
Zdroj: | European Journal of Applied Physiology. 121:3409-3419 |
ISSN: | 1439-6327 1439-6319 |
Popis: | Bolus intravenous administration of 0.9% saline has been associated with the development of pulmonary edema, and increased mortality. An animal model has previously demonstrated that rapid intravenous administration of 0.9% saline was associated with non-hydrostatic lung injury with increased lung lavage protein. We hypothesized that this non-hydrostatic effect would also occur in human volunteers. In a randomized, cross-over study of 14 healthy male subjects, the lung lavage protein concentration and cardiorespiratory effects of an intervention with rapid intravenous administration of 30 mL/kg of 0.9% saline were compared with sham intervention. Bronchoalveolar lavage (BAL) was performed after fluid administration. Doppler echocardiography, lung ultrasound, pulmonary function tests, and blood sampling were performed before and after each intervention. The BAL total protein concentration was greater after 0.9% saline administration than with sham (196.1 µg/mL (SD 87.6) versus 129.8 µg/mL (SD 55.4), respectively (p = 0.020). Plasma angiopoietin-2 concentration was also increased to 2.26 ng/mL (SD 0.87) after 0.9% saline administration compared with sham 1.53 ng/mL (SD 0.69) (p |
Databáze: | OpenAIRE |
Externí odkaz: |