Inhibition of telomerase activity and SK-OV-3/DDP cell apoptosis by rhodium(III) and iron(III) complexes with 4′-(3-thiophenecarboxaldehyde)-2,2′:6′,2″-terpyridine
| Autor: | Zhen-Feng Wang, Bi-Qun Zou, Qing-Min Wei, Shu-Long Wang, Hong Liang, Ming-Xiong Tan, Qi-Pin Qin, Peng-Fei Yao |
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| Rok vydání: | 2019 |
| Předmět: |
Cisplatin
Telomerase Ligand Cell 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Molecular biology 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound medicine.anatomical_structure chemistry Apoptosis Materials Chemistry medicine Telomerase reverse transcriptase Physical and Theoretical Chemistry Terpyridine 0210 nano-technology Cytotoxicity medicine.drug |
| Zdroj: | Inorganic Chemistry Communications. 102:180-184 |
| ISSN: | 1387-7003 |
| DOI: | 10.1016/j.inoche.2019.02.030 |
| Popis: | Two rhodium(III) and iron(III) complexes of 4′-(3-thiophenecarboxaldehyde)-2,2′:6′,2″-terpyridine (tpatpy): [Rh(tpatpy)Cl3]·CH3OH (tpatpy-Rh) and [Fe(tpatpy)Cl3] (tpatpy-Fe) have been prepared and characterized. Tpatpy-Rh (5.03 ± 1.15 μM) and tpatpy-Fe (18.02 ± 0.45 μM) exhibited greater cytotoxicity than the tpatpy ligand (70.11 ± 0.28 μM) and cisplatin (61.21 ± 1.39 μM) against SK-OV-3/DDP cells. In addition, tpatpy-Rh inhibited telomerase by down-regulation of c-myc and hTERT, as well as induced SK-OV-3/DDP cell arrest in the S phase. |
| Databáze: | OpenAIRE |
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