The Relationship Between Sleep Disturbance and Pulmonary Function in Stable Pediatric Cystic Fibrosis Patients
| Autor: | Raouf S. Amin, Kathleen A. Burklow, Jennifer Jeffries, Judy A. Bean |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
Sleep disorder medicine.medical_specialty business.industry Respiratory disease Actigraphy Critical Care and Intensive Care Medicine medicine.disease Sleep in non-human animals Pulmonary function testing Endocrinology Dyssomnia El Niño Internal medicine medicine Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Chest. 128:1357-1363 |
| ISSN: | 0012-3692 |
| Popis: | Background Cystic fibrosis (CF) is the most common inherited disease affecting northern European populations. It is characterized by a progressive clinical course that causes diurnal and nocturnal pulmonary and gastrointestinal symptoms. Objectives To determine whether clinically stable pediatric patients with CF have lower sleep efficiency than healthy control subjects, and to examine the relationship between sleep efficiency and pulmonary function. Methods Forty-four CF patients and 40 control subjects completed 5 days of actigraphy recordings. Additionally, sleep questionnaires were independently completed by all study participants and their parents. Pulmonary function testing was performed in all patients with CF. Multiple regression analysis was used to measure the independent correlation between sleep variables and pulmonary function. Results CF patients had significantly lower sleep efficiency than control subjects. The FEV 1 of these patients correlated positively with sleep duration and efficiency, and negatively with the number and duration of nocturnal awakenings, age, and body mass index (BMI). The independent effect of FEV 1 on sleep was first examined. Age and FEV 1 were the only variables that predicted sleep duration ( R 2 = 0.3; p=0.0007), while FEV 1 was the only variable predicting sleep efficiency ( R 2 = 0.28; p=0.0002). When the independent effect of sleep on FEV 1 was analyzed, sleep efficiency, BMI percentile, and gender predicted FEV 1 ( R 2 = 0.46; p ≤ 0.0001). The frequency of nocturnal cough reported by patients and their parents was an independent predictor of FEV 1 . Conclusions Pediatric patients with CF and stable pulmonary function have lower sleep efficiency and more frequent nocturnal awakenings than do healthy control subjects. After adjustment for demographic characteristics, there was an independent and significant correlation between sleep parameters and FEV 1 , when either sleep variables or FEV 1 were used as dependent variables. These findings suggest a bidirectional relationship between sleep disturbance and CF lung disease. |
| Databáze: | OpenAIRE |
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