Blue Mussel (Mytilus edulis) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats
| Autor: | Alan Darmasaputra Ong, Zwe-Ling Kong, Yu-Wen Yen, Heng-Wei Chang, Chien-Feng Mao, Sabri Sudirman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology business.industry Anterior cruciate ligament Inflammation Osteoarthritis medicine.disease medicine.disease_cause Obesity Proinflammatory cytokine Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure 030202 anesthesiology Weight loss Internal medicine biology.protein Medicine medicine.symptom business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Pain Research. 13:1109-1119 |
| ISSN: | 1178-7090 |
| Popis: | Purpose To investigate the effects of Mytilus edulis water extract (MWE) on an anterior cruciate ligament transection and a partial medial meniscectomy surgery to induced osteoarthritis (OA) with the high-fat diet (HFD)-induced obese rats. Methods The male Sprague-Dawley rats were fed with HFD for 4 weeks before surgery. The OA rats were orally administered with MWE (108.5, 217.0, and 542.5 mg/kg) for 6 weeks. Results The administration of MWE affected weight loss, triglycerides content, and total cholesterol level. MWE also enhanced the activity of superoxide dismutase and decreased lipid peroxidation degree. Moreover, MWE reduced proinflammatory cytokines level, alleviated inflammation and swelling of the osteoarthritic knee, and reduced loss of proteoglycan in articular cartilage tissue. Conclusion MWE suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis rats under obesity condition. Therefore, MWE has the potential to act as an alternative for osteoarthritis treatment. |
| Databáze: | OpenAIRE |
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