Investigation of On-Resin Disulfide Formation for Large-Scale Manufacturing of Cyclic Peptides: A Case Study

Autor:	Lena Hansen, Yi Yang, Fabrizio Badalassi
Rok vydání:	2020
Předmět:	chemistry.chemical_classification chemistry 010405 organic chemistry Organic Chemistry Disulfide bond Rink amide resin Peptide Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Cyclic peptide 0104 chemical sciences
Zdroj:	Organic Process Research & Development. 24:1281-1293
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00168
Popis:	Peptide molecules bearing disulfide moieties constitute an important category of therapeutics. The establishment of the disulfide structure plays a pivotal role in the production of those peptides....
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2dc4b0c3159548276857c51428d8673 https://doi.org/10.1021/acs.oprd.0c00168 Zobrazit plný text záznamu