| Popis: |
Studies with herpes simplex virus have shown that herpesvirus glycoproteins are incorporated into the plasma membrane of host cell (1,2), eventually make up part of the virion envelope (3,4), and, among other biological and immunological functions, effect attachment and penetration of the virus into the cell (4,5). The cell surface receptors involved, however, have not been identified. It has been reported that bovine herpesvirus 1 (BHV-1) has more than 25 structural polypeptides (6,7), 11 of which are glycosylated, and indirect evidence (8,9) indicates that some of these glycoproteins are involved in viral attachment to the host cell. As with herpes simplex virus, the structure and distribution of the cell surface receptors have not been determined. Recently, anti-idiotypic (anti-Id) antibodies have been utilized to define ligand receptors (10,11) and cell surface receptors for reovirus (12). We have used a similar approach in an attempt to characterize the cell surface receptor for BHV-1. |
