The etiology of agents of infectious complications after transplantation of liver and kidneys and their resistance to antibiotics
| Autor: | D. G Akhaladze, T. S Spirina, T. B Safonova, M. N. Kornilov, L. G Stolyarova, O. A Savostyanova, N. I. Gabrielyan, E. M Gorskaya, I. E Tsirulnikova |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Medical Journal of the Russian Federation. 22:232-237 |
| ISSN: | 2412-9100 0869-2106 |
| Popis: | The study was carried out to investigate etiology and rate of prevalence of nosocomial strains of microbes in biosubstrates of patients in case of development of infectious complications and level of their resistance to various groups of antibiotics. The retrospective analysis of agents of post-operational infectious complications and their sensitivity to antibiotics in 99 patients after operations of transplantation of liver and kidneys in 2013. The patients were allocated on three groups: group I - patients of department of reanimation and intensive therapy after mentioned operations (17 individuals); group II (42 individuals) - after orthotopic transplantation of liver (19 patients) and orthotopic transplantation of kidneys (23 patients); group III (57 patients) - after kindred transplantation of hepatic lobe from living relative donor. The retrospective analysis of agents of post-operational infectious complications in patients underwent transplantation of liver and kidneys demonstrated that out of 1285 identified strains of microbes, 60.8% were presented by Gram-positive microflora with predominance of coagulase-negative staphylococci and enterococci. Among Gram-negative microflora, enterobacteria comprised the largest percentage (61%). The analysis of antibioticgrams of agents of infectious complications established low level of sensitivity of strains of both Gram-positive and Gram-negative microbes isolated from patients of department of reanimation and intensive therapy and to carbapenems and average level of sensitivity to Tigacil. In overall, poly-resistance of strains was established. The differences in antibiotics resistance for strains of pathogens isolated in department of reanimation and intensive therapy and specialized departments were established. The received data can be used for correction of application of antibiotics in prevention and therapy of post-operational infectious complications. |
| Databáze: | OpenAIRE |
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