| Autor: |
Angélica María González-Clavijo, Andrés A. Cuellar, Jenny Triana-Urrego, Jorge A. Barrero, Luis Felipe Fierro-Maya |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Endocrine. |
| ISSN: |
1559-0100 |
| DOI: |
10.1007/s12020-023-03302-0 |
| Popis: |
Purpose To describe the overall survival and progression-free survival in patients diagnosed with differentiated thyroid carcinoma with synchronous and metachronous metastatic involvement. Materials and methods A retrospective cohort study was conducted with 101 patients with differentiated thyroid cancer (DTC) who had metastatic involvement at diagnosis or during follow-up, who were treated at the National Cancer Institute between January 1, 2010 and December 31 of 2015. Results 81 patients (80.2%) were women and the mean age at diagnosis was 49 years (12–80). Synchronous metastases were detected in 54.5% of patients and metachronous metastasis was diagnosed in 45.5% of patients, in whom the mean time between initial diagnosis and the finding of distant metastases was 5 years. Pulmonary involvement occurred in almost all patients, with 131I uptake in 58% of synchronous metastases and in 21% of metachronous. There were 10 events in the patients with 131I-avid metastases with a median time to progression that was not reached, and there were 23 events in patients with 131I-refractory metastases with a median time to progression of 96 months; The median time to progression was significantly longer in patients with synchronous metastases compared to those with metachronous metastases (Not reached vs 95 months, P = 0.017) The 5-year overall survival rate was 95% to the entire cohort. Conclusions The present study contributes to the expansion of the knowledge about this clinical course of DTC with the finding of a worst prognosis in patients with metachronous metastases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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