Nucleophilic Substitution on 4–Nitro– and 4–Methoxy–3–pyridinecarboxylic Acid–1–oxides

Autor:	Viktor Prutianov, Svatava Voltrová
Rok vydání:	1997
Předmět:	Substitution reaction Organic Chemistry Pharmaceutical Science Alkylation Medicinal chemistry Analytical Chemistry chemistry.chemical_compound chemistry Nucleophile Chemistry (miscellaneous) Nucleophilic aromatic substitution Drug Discovery Nitro Nucleophilic substitution Molecular Medicine Organic chemistry Acid hydrolysis Physical and Theoretical Chemistry Bromoethane
Zdroj:	Molecules. 1:207-211
ISSN:	1420-3049
DOI:	10.1007/s007830050039
Popis:	1-Oxides of 4-nitro-3-pyridinecarboxylic acid (3) and methyl 4-methoxy-3-pyridinecarboxylate (5) were converted to 4-(diphenylmethyl)amino (7), 4-phenylthio (8), 4-phenylamino (9) and 4-(2-methylpropyl)-amino (6) derivatives by reaction with the corresponding nucleophiles. The 4-phenylamino derivative 9 was alkylated with bromoethane to form the corresponding ethyl ester of the 1-ethoxypyridinium salt 10.
Databáze:	OpenAIRE
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