Effect of Organic Germanium Compound (Ge-132) on Experimental Osteoporosis in Rats: The Relationship Between Transverse Strength and Bone Mineral Density (BMD) or Bone Mineral Content (BMC)

Autor:	Akira Fujii, Junichi Yamane, Hiroko Matsumoto, Gui-Zhen Jiang, Noboru Kuboyama, Takafumi Hashimoto, Kiichi Nonaka
Rok vydání:	2002
Předmět:	musculoskeletal diseases Bone mineral medicine.diagnostic_test Osteoporosis chemistry.chemical_element Germanium Anatomy musculoskeletal system medicine.disease Transverse plane Animal science chemistry medicine Ovariectomized rat Bone mineral content Femur Quantitative computed tomography
Zdroj:	International Journal of Oral-Medical Sciences. 1:10-16
ISSN:	2185-4254 1347-9733
DOI:	10.5466/ijoms.1.10
Popis:	The antiosteoporotic effect of organic germanium compound, poly-trans-(2-carboxyethyl)germaniumsesquioxide (Ge-132), was studied using ovariectomized rats maintained on a low calcium diet. Rats without ovariectomy and maintained on a normal commercial diet gave the highest femur transverse strength as well as the highest BMD or BMC, measured by peripheral quantitative computed tomography (pQCT) of the femur bone. A daily dose of 18 mg/kg gave the highest femur transverse strength among the dose schedules of 0, 0.5, 3.0, 18.0, and 108.0 mg/kg/day, after both 3 and 6 months in ovariectomized rats maintained on a low calcium diet. Morphological analysis of the femur, especially weight and outside diameter also supported that Ge-132 enhances the femur transverse strength. The pQCT measurements of the femur demonstrated that a high correlation existed between the transverse strength and total BMD or BMC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2c6fcb31d82555244baf1fffdf0a31c https://doi.org/10.5466/ijoms.1.10 Zobrazit plný text záznamu