Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity

Autor:	Qi-Li Mi, Gan-Peng Li, Wang Jin, Guang-Yu Yang, Dian Luo, Yin-Ke Li, Qiu-Fen Hu, Yan-Qing Ye, Li-Jun Zhu, Na Lv, Kong Weisong, Qian Gao, Ying Guan
Rok vydání:	2020
Předmět:	Antioxidant biology 010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment Nicotiana tabacum Plant Science General Chemistry medicine.disease_cause biology.organism_classification 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry Staphylococcus aureus medicine IC50 Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Chemistry of Natural Compounds. 56:806-810
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-020-03157-1
Popis:	Two new coumarins, 6-hydroxymethyl-3-prenyl-7-methoxycoumarin (1) and 6-hydroxyethyl-3-prenyl-7- methoxycoumarin (2), together with three known coumarins (3–5), were isolated from the roots and stems of Yunyan-300, a variety of Nicotiana tabacum L. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillinresistant Staphylococcus aureus (anti-MRSA) activity and their antioxidant activity. The results revealed that compounds 1 and 2 showed good anti-MRSA inhibitions with IZD of 12.2 ± 1.8 and 11.8 ± 1.5 mm, respectively, and antioxidant activity with an IC50 value of 4.65 and 4.85 μg/mL, respectively.
Databáze:	OpenAIRE
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