| Autor: |
Shunsuke Nagano, Kennichi Nishimura, Yasuji Ichikawa, Yukiomi Namba, P. Dalquen, Takanobu Fukunishi, Fred Gudat, Michael J. Mihatsch, Masahiro Kyo, Kiyohide Toki |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Clinical Transplantation. 16:40-44 |
| ISSN: |
0902-0063 |
| DOI: |
10.1034/j.1399-0012.16.s8.8.x |
| Popis: |
A total of 9000 urine samples from 69 kidney transplant recipients were studied for differential diagnoses of transplant rejection and cyclosporin/tacrolimus toxicity. New-Sternheimer and Papanicolaou staining were used to differentiate cells in urine. We also employed an immunocytochemical technique for further identification of exfoliated cells. With New-Sternheimer and Papanicolaou staining, the predominance of proximal tubular cells was useful to differentiate cyclosporin/tacrolimus toxicity from acute rejection in cases of increased serum creatinine level. During rejection episodes, an increased number of mononuclear cells and renal epithelial cells were found. Immunocytochemical analysis showed a significant increase of CD2-, CD4- CD8-, CD25- and HLA-DR-positive cells with rejection. However, there was no relationship between Banff criteria rejection grade and the increase of mononuclear cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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