| Autor: |
V. Macheraki, N. Demopoulos, M. Kokkinaki, D. H. Spathas, G. Stephanou, N. Moschonas, V. Orphanos, G. M. Maniatis, S. Kamakari |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Analytical Use of Fluorescent Probes in Oncology ISBN: 9781461376798 |
| DOI: |
10.1007/978-1-4615-5845-3_45 |
| Popis: |
Deletions or loss of heterozygosity in certain regions of the long arms of human chromosomes 6 and 10 have been reported over the last few years in several types of malignancies; more specifically, region 6ql6.3-q21 is frequently deleted in patients with acute lymphoblastic leukemia1 (ALL) and the same region, as well as 6q25-qter are often deleted in patients with Non-Hodgkins lymphoma1; loss of heterozygosity in both these regions has also, been documented in breast2 and ovarian3 cancer. In addition, loss of heterozygosity within the 10q23-24 region has been reported in patients with prostate cancer4 and patients with glioblastoma multiforme5. These observations suggest the presence of tumor-suppressor gene(s) in these regions and, therefore, detailed physical mapping may lead to the identification and subsequent isolation of such genes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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