Sucrose esters and xanthones from Polygalakarensium
| Autor: | Nguyen Minh Khoi, Tran Van Quang, Bui Huu Tai, Phan Van Kiem, Vu Van Doan, Nguyen Thi Cuc, Pham Thi Nguyet Hang, Nguyen Thuong Dong, Nguyen Xuan Nhiem, Dao Anh Dung |
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| Rok vydání: | 2020 |
| Předmět: |
Mitoxantrone
Sucrose Chromatography biology 010405 organic chemistry Cancer Plant Science medicine.disease biology.organism_classification 01 natural sciences Biochemistry Polygala 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Bromide Xanthone medicine Cytotoxic T cell Polygalaceae Agronomy and Crop Science Biotechnology medicine.drug |
| Zdroj: | Phytochemistry Letters. 37:75-79 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2020.04.010 |
| Popis: | Using various chromatographic methods, two new sucrose esters, karensucrose A (1) and karensucrose B (2), one new xanthone, karenxanthone (7) along with eight known compounds, 3-(E)-3,4,5-trimethoxycinnamoyl-6′-benzoylsucrose (3), tricornose B (4), glomeratose C (5), tenuifoliside C (6), 1,7-dihydroxyxanthone (8), 1-methoxy-7-hydroxyxanthone (9), 1,7-dimethoxy-6-hydroxyxanthone (10), and wubangziside B (11) were isolated from the roots of Polygala karensium Kurz (Polygalaceae). Their chemical structures were elucidated using spectroscopic and chemical methods and compared with the reported literature. All isolated compounds were evaluated for cytotoxic activity against two human cancer cell lines, human breast cancer (MCF7) and human prostate cancer (PC3) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Mitoxantrone was used as a positive control with IC50 values of 9.7 ± 1.2 μM (MCF7) and 7.4 ± 1.3 μM (PC3). As the results, compound 8 showed cytotoxic activity on MCF7 and PC3 cancer cell lines with IC50 values of 26.2 ± 2.1 and 22.1 ± 1.7 μM, respectively. |
| Databáze: | OpenAIRE |
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