| Autor: |
Islaine de Souza Salvador, Renata Da Silva Leite, Fábio Santos de Souza, Rayanne Sales de Araújo Batista, Fabrício Havy Dantas de Andrade, Valmir Gomes de Souza, Rui Oliveira Macêdo |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmacy and Pharmaceutical Sciences. 9:154 |
| ISSN: |
0975-1491 |
| DOI: |
10.22159/ijpps.2017v9i4.16743 |
| Popis: |
Objective : The aim of this research was to evaluate the acute and sub-acute oral toxicities of the nebulized dried extract of Myracrodruon urundeuva (NDEMU) leaf obtained by the spray drying technique on rabbits. Methods : In the acute toxicity study, the amount of nebulized dried extract (NDE) administered was adjusted to a dose of 2000 mg/kg of leaf powder of M. urundeuva to 6 rabbits once orally and were observed for 14 days. In the sub-acute study, the amount of NDEMU administered was adjusted to a dose of 2000 mg/kg/day of to 6 rabbits once daily for 30 day, orally. The appearance of toxic symptoms was observed every day, followed by each rabbits' food and drink intake. Haematological and biochemical analysis were observed and statistical analysis was performed on them. The rabbits were killed at the end of the study, and their organs were weighed and examined before organ histology were evaluated. Results : No toxic signs and no mortality were observed in the acute and sub-acute study. In the sub-acute study, the amount of dried extract administered was adjusted to a dose of 2000 mg/kg of leaf powder of M. urundeuva to 6 rabbits once daily for 30 days, orally. No toxic signs and no mortality were observed. There were no significant changes (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
