18 F-FDG PET/CT in immunocompetent patients with primary central nervous system lymphoma: Differentiation from glioblastoma and correlation with DWI
| Autor: | Xiuhong Lu, Daoying Geng, Bo Yin, Weixingzi Xu, Weiyan Zhou, Yihui Guan, Jianbo Wen, Fengchun Hua |
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| Rok vydání: | 2018 |
| Předmět: |
PET-CT
medicine.diagnostic_test Receiver operating characteristic business.industry Primary central nervous system lymphoma Area under the curve Standardized uptake value General Medicine medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Positron emission tomography hemic and lymphatic diseases 030220 oncology & carcinogenesis medicine Effective diffusion coefficient Radiology Nuclear Medicine and imaging business Nuclear medicine Diffusion MRI |
| Zdroj: | European Journal of Radiology. 104:26-32 |
| ISSN: | 0720-048X |
| Popis: | Objectives 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is useful for the detection of cancerous lesions, and FDG uptake is related to the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of extracranial tumors. The purpose of our study was to investigate the ability of FDG PET/CT in distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM) and to explore the relationship between 18F-FDG uptake and the ADC in patients with PCNSL. Methods We reviewed 92 patients (40 with PCNSL and 52 with GBM) who underwent FDG PET/CT scans at disease onset. The maximum standardized uptake value (SUVmax), tumor to normal contralateral cortex activity (T/N) ratio, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of tumor lesions were calculated. Receiver operating characteristic (ROC) curves were generated to determine the diagnostic performance for FDG PET-related parameters to differentiate PCNSL from GBM. Twenty-eight patients with PCNSL (with 34 lesions) also underwent diffusion-weighted imaging. Pearson’s correlation analysis was used to assess the relation between SUV- and ADC-derived parameters. Results The SUVmax, T/N ratio, SUVmean, and TLG values were significantly higher in PCNSL than in GBM. Comparative ROC analysis indicated that the SUVmax had a greater area under the curve (AUC) of 0.910 than the T/N ratio (0.905, P = .85), SUVmean (0.836, P = .0006), or TLG (0.641, P Conclusions The SUVmax and T/N ratio may be reliable measures for differentiating PCNSLs from GBMs. Additionally, FDG metabolism indices were inversely proportional to the rADCs of PCNSL lesions. |
| Databáze: | OpenAIRE |
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