| Autor: |
René Wilbers, Verjinia D. Metodieva, Sarah Duverdin, Djai B. Heyer, Anna A. Galakhova, Eline J. Mertens, Tamara D. Versluis, Johannes C. Baayen, Sander Idema, David P. Noske, Niels Verburg, Ronald B. Willemse, Philip C. de Witt Hamer, Maarten H. P. Kole, Christiaan P.J. de Kock, Huibert D. Mansvelder, Natalia A. Goriounova |
| Rok vydání: |
2022 |
| Popis: |
Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet have surprisingly fast input-output properties: rapid subthreshold synaptic membrane potential changes are reliably encoded in timing of action potentials (APs). Here, we tested whether biophysical properties of voltage-gated sodium (Na+) and potassium (K+) currents in human neurons can explain their fast input-output properties. Human Na+and K+currents had depolarized voltage-dependence, slower inactivation and exhibited a faster recovery from inactivation than their mouse counterparts. Computational modeling showed that despite lower Na+channel densities in human neurons, the biophysical properties of Na+channels resulted in higher channel availability and explained fast AP kinetics stability. Finally, human Na+channel properties also resulted in a larger dynamic range for encoding of subthreshold membrane potential changes. Thus, biophysical adaptations of voltage-gated Na+and K+channels enable fast input-output properties of large human pyramidal neurons.One-Sentence SummaryBiophysical properties of Na+and K+ion channels enable human neurons to encode fast inputs into output. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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