Abstract 082: Oral Minocycline Reduces Blood Pressure and Restores Autonomic Balance in Chronic Ang II-Infusion Rat Model of Hypertension
| Autor: | Monica M Santisteban, Jasenka Zubcevic, Jessica Marulanda-Carvajal, Michael Zingler, Mohan K Raizada |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Hypertension. 64 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hyp.64.suppl_1.082 |
| Popis: | Introduction: We have established that microglial activation and dysfunctional autonomic nervous system (ANS) are associated with Ang II hypertension (HTN). The objective of this study was to test the hypothesis that oral delivery of minocycline (Mino), an anti-inflammatory antibiotic that crosses the blood brain barrier, would impact PVN microglia activation, improve autonomic function, and reverse HTN. Methods: SD rats irradiated and reconstituted with donor eGFP bone marrow (BM) cells were infused with saline or 200ng/kg/min Ang II S.C. for 7 wks. Additionally, rats received vehicle or Mino (50 mg/kg) by oral gavage. MAP was measured weekly by telemetry (n=3/group) and tailcuff (n=9/group). Spectral analysis of telemetry BP signal was performed for ZT12-13 at 3 wks to reveal autonomic balance. Results: Ang II increased MAP vs control (178±9 mmHg vs 104±2 mmHg; p Conclusions: These observations demonstrate that oral Mino treatment inhibits microglia activation, attenuates autonomic dysfuction and peripheral inflammation that arrests the progression of HTN. This suggests that Mino might be an effective therapeutic agent to target neurogenic HTN. |
| Databáze: | OpenAIRE |
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