P.2.016 Exposure to an alternative reward does not reduce cocaine-seeking behaviour

Autor: C. Lafay-Chabassier, M. Solinas, C. Nicolas
Rok vydání: 2013
Předmět:
Zdroj: European Neuropsychopharmacology. 23:S39-S40
ISSN: 0924-977X
DOI: 10.1016/s0924-977x(13)70044-0
Popis: on attention, impulsivity and performance in adult rats separated into high and low-performers in the 5C-CPT. The effects of acute methylphenidate (MPH) 0.5, 1.0, and 2.0mg/kg i.p, and atomoxetine (ATMX) 0.2, 1.0, 2.0mg/kg i.p were assessed in the 5C-CPT in female Lister-hooded rats (n = 40). Animals were trained for 60 sessions and then divided into two groups (high and low performers) based on set criteria. Animals were challenged on test days by increasing the inter-trial interval (ITI) from 5s to 10s. ATMX significantly reduced premature responding in low performers at 1.0 and 2.0mg/kg (p< 0.05). ATMX (2.0mg/kg) significantly increased % accuracy and reduced false alarm rate (p< 0.05) in poor performers. ATMX (1.0mg/kg, 2.0mg/kg) significantly increased sensitivity index in low performers (p< 0.05; p< 0.01), and significantly decreased responsivity index (p< 0.05) MPH at 2.0mg/kg significantly improved accuracy (p< 0.05), and reduced premature responding (p< 0.05) in low performers and increased premature responding in high performers (p< 0.05). MPH significantly increased correct rejections in high performers at 2.0mg/kg (p< 0.05), and decreased correct rejections at all doses in low performers (p< 0.01, p< 0.05, p< 0.05 respectively). MPH significantly increased sensitivity index in low performers at 0.5 and 1.0mg/kg (p< 0.01). In summary, ATMX (noradrenaline reuptake inhibitor, non-stimulant) reduced impulsivity in low performers in both the 5-CSRTT (premature responses) and in the 5C-CPT (false alarm rate). ATMX enhanced sustained attention in the 5CSRTT and vigilance in 5C-CPT in low performers. Methylphenidate (dopamine/noradrenaline reuptake inhibitor, psychostimulant) enhanced sustained attention in the 5-CSRTT, vigilance in the 5C-CPT (% correct rejections) and marginally reduced impulsivity in low performers in the 5C-CPT. This would suggest that low performers are more sensitive to the effects of both stimulant and non-stimulant drugs. These data provide the validation of a rat model for the inattentive subtype of adult ADHD. The model utilises the 5C-CPT to select for those with deficits in sustained attention and vigilance, which can then be enhanced by ADHD medication.
Databáze: OpenAIRE
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