Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001-2016
| Autor: | Bjørn Heine Strand, Petja Lyn Langholz, Laila Arnesdatter Hopstock, Sarah Cook |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Proportional hazards model Population Norwegian medicine.disease Comorbidity language.human_language 03 medical and health sciences 0302 clinical medicine Epidemiology medicine language 030212 general & internal medicine business Prospective cohort study education 030217 neurology & neurosurgery Cohort study Cause of death Demography |
| Zdroj: | Geriatrics & Gerontology International. 18:1200-1205 |
| ISSN: | 1444-1586 |
| DOI: | 10.1111/ggi.13447 |
| Popis: | Aim There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study. Methods We followed 712 participants (52% women) aged ≥70 years participating in the population-based Tromso 5 Study in 2001-2002 for all-cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried's frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education. Results In total, 3.8% (n = 27) of participants were frail (women 4.4%, men 3.2%) and 38.1% (n = 271) were pre-frail (women 45.8%, men 29.9%). During follow-up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail older adults (multivariable-adjusted HR 4.16, 95% CI 2.40-7.22) compared with non-frail older adults. In sex-stratified analysis, the adjusted HR was 7.09 (95% CI 3.03-16.58) for frail men and 2.93 (95% CI 1.38-6.22) for frail women. Results for pre-frailty showed an overall weaker association with mortality. Conclusions While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. Geriatr Gerontol Int 2018; 18: 1200-1205. |
| Databáze: | OpenAIRE |
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