| Autor: |
Peter G. Jones, Bastian Milde, Daniel B. Werz, Martin Pawliczek |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
ChemInform. 46 |
| ISSN: |
0931-7597 |
| Popis: |
An intramolecular domino process consisting of a formal anti-carbopalladation followed by Heck reaction is realized. Complex oligo(hetero)cyclic scaffolds are efficiently obtained in one synthetic step from easily obtainable enyne precursors. In contrast to common syn-carbopalladation reactions of alkyne units, the carbopalladation employed here is designed to afford an anti-arrangement of the two new substituents across the emerging double bond. A prerequisite is that the residues next to the alkyne should lack any β-hydrogen atoms. The method paves the way to tri- and tetrasubstituted double-bond systems that have not been accessible by conventional Pd catalysis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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