| Autor: |
David K. Detweiler, Kaufman Laura |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Toxicology Methods. 9:285-292 |
| ISSN: |
1051-7235 |
| DOI: |
10.1080/105172399242636 |
| Popis: |
This communication describes an axial electrocardiogram (ECG) lead configuration intended torecord maximal T wave amplitudes of unrestrained, conscious cynomolgus monkeys. The impetus for this work came from the need to develop a cynomolgus monkey model to evaluate potential effects of novel pharmaceuticals on the QT interval. A large-animal model is needed as an alternative to the dog in instances involving atypical canine metabolism or overly sensitive canine emetic responses to novel pharmaceuticals. Under anesthesia, a negative ECG lead was implanted at the base of the right side of the neck and a positive lead was implanted under the left nipple, or fifth intercostal space near the sternum. Twenty-four-hour data collection occurred in the animals'home cages using radiotelemetry beginning at least 2 weeks following implant surgery. A total of 123 ECGs from 11 male and 3 female cynomolgus monkeys were analyzed across the physiologic range of heart rates (RR intervals of 300-900 ms). The longest RR inte... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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