Utilization of precursor steroids in placental progesterone**The trivial names used throughout this paper are: progesterone=preg-4-ene-3, 20-dione; pregnenolone=3β-hydroxy-pregn-5-en-20-one; cholesterol=cholest-5-en-3β-ol; 20α-dihydroprogesterone=20α-hydroxy-pregn-4-en-3-one; 20β-dihydroprogesterone=20β-hydroxy-pregn-4-en-3-one; 20β-dihydropregnenolone=pregn-5-ene-3β, 20β-diol; 20α-dihydropregnenolone=pregn-5-ene-3β, 20a-diol; pregnenolone sulfate=pregn-5-ene-3β-yl sulfate; cholesterol sulfate=cholest-5-en-3β-yl sulfate; 20β-pregnenolone sulfate=20β-hydroxypregn-5-en-3β-yl sulfate; 20α-dihydroprogesterone sulfate=pregn-4-ene-3-one-20α-yl sulfate. synthesis

Autor:	Ronald J. Pion, Suzanne H. Conrad, James D. Kitchin, Pei-Chuan Ouyang
Rok vydání:	1969
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment Obstetrics and Gynecology Sterol Progesterone synthesis Steroid Term placenta chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine medicine Pregnenolone Pregnenolone sulfate business medicine.drug
Zdroj:	American Journal of Obstetrics and Gynecology. 103:48-55
ISSN:	0002-9378
DOI:	10.1016/s0002-9378(16)34339-3
Popis:	A number of radioactive steroid and sterol compounds were infused into the human term placenta in situ in an effort to assess their potential as precursors for progesterone production. Pregnenolone and pregnenolone sulfate were most efficiently converted to progesterone (12.8 and 12.9 per cent of injected radioactive material). 20β-dihydroprogesterone, 20β-dihydropregnenolone, and 20β-dihydropregnenolone-3-sulfate were converted in very low yield (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e250b968338bb9ee49cfaf47893fc5c7 https://doi.org/10.1016/s0002-9378(16)34339-3 Zobrazit plný text záznamu